Habits and Hustle - Episode 279: Colleen Cutcliffe: How to Heal Your Gut, Control Your Glucose Levels, and Speed Your Metabolism

Episode Date: September 26, 2023

In this episode of Habits and Hustle, I chat with Colleen Cutcliffe who gives us a step-by-step guide on all things gut health – understanding why optimization is key, why it’s growing in popularity, how your gut is controlling you, and exactly what you should do to reclaim your gut microbiome. We also dive into how the gut is linked to your metabolism, the popular trend of glucose control and why we should be concerned about our glucose levels, and why an increasing number of people are seeking natural alternatives to metformin. Colleen Cutcliffe is the CEO and Co-Founder of Pendulum Therapeutics. Colleen has over 20 years of experience managing and leading teams in biotech, pharma, and academia. Before starting Pendulum Therapeutics, Colleen served as the Senior Manager of Biology at Pacific Biosciences, which is where she met her two co-founders. Prior to that, Colleen was a Scientist at Elan Pharmaceuticals. Colleen completed her postdoctoral research at Northwestern’s Children’s Memorial Hospital, received her Ph.D. in Biochemistry and Molecular Biology from Johns Hopkins University and received her B.A. in Biochemistry from Wellesley College. Use code “JENCOHEN” for 20% off of your first bottle of membership at pendulumlife.com What we discuss: (0:09:01) - Akkermansia's Role in Gut Health (0:17:41) - GLP-1 and Akkermansia in Metabolism (0:31:36) - Longevity Drugs and Glucose Control (0:35:01) - Glucose Control and Metabolic Supplement Benefits (0:45:16) - Gut Health Benefits and Quality Control (0:57:15) - Understanding Acromantia and Its Benefits Thank you to our sponsors: Pendulum: Head over to www.pendulumlife.com and use code JENCOHEN for 20% off. Therasage: Head over to therasage.com and use code Be Bold for 15% off Ketone IQ (HVMN): You can save 30% off your first subscription order of Ketone-IQ at HVMN.com/JEN Find more from Jen:  Website: https://www.jennifercohen.com/ Instagram: @therealjencohen  Books: https://www.jennifercohen.com/books Speaking: https://www.jennifercohen.com/speaking-engagement Learn more from Colleen Cutcliffe: Website: https://pendulumlife.com/ Instagram: https://www.instagram.com/pendulumlifeco/ Learn more about your ad choices. Visit megaphone.fm/adchoices

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today at publicmobile.ca. Different is calling. Hi guys, it's Tony Robbins. You're listening to Habits in Hustle. Creshed. So, we're doing a podcast today with Colleen Cutcliffe, who is the CEO of a company called Pendulum. And the reason why we're doing this podcast, just to kind of be complete transparent, is would you call yourself a microbiome, scientific, would you say, what would you call the company before I kind of go into my whole spiel? And the reason why I'm asking is because the reason why we're doing this is your products are so much different

than the other products on the market. And when I say that, is my own experiences with microbiome, with what it's done for my health. It's been so incredible that I wanted to share this with my audience with you guys. I wanted to introduce Colleen because she is the inventor and the one who brought this whole thing to life. And that's what I'm saying. Because it helps with so many different things, but I see it as a gut microbiome, I guess, supplement

company. Would that be accurate? Well, we're really a biotech company at the heart of it. So it is. It's a microbiome biotech company and the products that we have now come in the form of a supplement and so they can look like a lot of the other supplements, but the way that they were designed, the way they've been tested, what they're intended to do, have really been developed like a biotech company. Yeah. And like I said, you guys are going to like hear why we're doing this with Colleen today because it really did change my health and because it really did change my health. And also a lot of people in my life and my friends who've actually seen a major difference,

they've taken, I was telling Colleen before, that people took their blood before using some of your products and after, and there was a significant difference in their overall, their biomarkers, were significantly better after taking your products. And my reason why, again, I'm doing this is because it's so congested, the space of,

especially anything in terms of supplements, microbiome, gut health, all of it. And so it's very hard to kind of cut through all the clutter and know what to do, how to do it. And when I really kind of delved into the science and like all the science that you guys have done and how you guys have really created something that is so unique, I wanted to help promote it and have you on. So that's a long way of saying thank you for being on my podcast. Thank you so much for having me. And I think the challenge that you're pointing to

is something that we think about a lot. And so I really appreciate you inviting me to come on because we don't get a lot of chances and opportunities to really help deep dive into what is different here. But I think everybody inherently kind of knows that gut health is important. And there's a lot of evidence that people have seen in their own lives and from their friends' lives knowing that if you have dysbiosis,

you can have all these issues that come with it. And if you have a healthy gut, you have all these really nice benefits. And so there are a lot of companies and people who are sort of taking advantage, frankly, of the fact that people really want to have good gut health. And so there's just a lot of misinformation out there for all of the well-intended people

who are just trying to be healthier. Right, right. When did it become such a trend or a fat, like I feel like five years ago, we didn't hear that much about gut health or the microbiome. And then something happened, there was a tipping point somewhere where it became all the rage,

where that was what everybody's talking about. And when anything becomes trendy, everybody in their dog jumps on that bandwagon, and then it's basically a free for all. And that's what I feel happening. Like I was saying to you, like all transparency, I get pitched, got health, probiotics, like on the daily, right?

And if, you know, I maybe I know a little bit more than the average Joe, just because of what I do for a living and how I get, you know, I get exposed to bit more than the average Joe, just because of what I do for a living and how I get exposed to more than maybe the average bear. But if you don't, it's so confusing. Can you first tell us why, and let's start from the basics. Let's actually, let's talk about your origin story. Like, who are you, which your background,

and then I wanna get into why God Health is so important for your overall health. Sure. And I'm happy to also talk about why it's become, God Health has become so trending in the last decade or so, the last five years. Okay, so my background is actually pretty hardcore science. I'm just good, right? I have a PhD in biochemistry and molecular biology from Johns Hopkins.

I did a pretty traditional postdoc at Northwestern and then I moved out to San Francisco where I worked for a pharmaceutical company. We were developing drugs for Parkinson's disease and so that's where I started to learn how drug development works. And then I did what everybody does in Silicon Valley. I joined a startup company. Right. It was a DNA sequencing instrument company. It went through rapid growth and we went public and on the other side of that IPO, I started this company. So up until starting this company, all of my work had been really an R&D and science and biology.

And so the reason why, and I started this company with two co-founders, we're all really technical. I'm a biochemist, gym and a bio-setician, John as a biophysicist, and we work together at that DNA sequencing company that went public. And the reason we wanted to start this company is because the microbiome, even though probiotics and yoghards have been on the shelves for decades, the microbiome is actually a new science. And if you look on PubMed, which is like a repository for publications, and you see like

how many publications were there about the microbiome over time, you're going to see a flat line at zero until about 2010 and then it starts to be exponential. And that's because DNA sequencing allowed us to look at all the different bugs in our microbiome and on our skin and that's what's enabled the microbiome to be a science. So now you can get out of all the same stuff that's in yogurts and probiotics on the shelves and start to really delve into the 99.9% of our gut

that nobody has ever been exposed to before. And so it's DNA sequencing and probiotics on the shelves and start to really delve into the 99.9% of our gut that nobody has ever been exposed to before. And so it's DNA sequencing that allowed the microbiome to become a real science. The American Gut Project was a huge project where they looked at microbiomes of like over 10,000 Americans and that's where they discovered that your gut is so important for all kinds of things that go beyond just GI issues like IBS and IBD and start to get into issues like your metabolism, your skin, your brain function. And so when that work came out, it really showed people how important your gut is.

And so for the last five years, I think people have really, a lot more data's been coming out, really continuing to build on that hypothesis. And so that's kind of how we ended up where we are now, where everybody knows how this really important, but they're still using some of the same old checks that were out there. That's why I wanted to ask you. So you create it, or like what makes you guys exceptionally

unique is that there's something called acrimansia. And that's a very unique strain that's never been put into a supplement form, correct? Well, yeah, it's really hard to manufacture. Really hard to manufacture. Because everyone hears about the say, I can't print lacto, blah, blah, blah, tea, whatever it is called, like most other companies who do supplements or what's on the market, what most are using is based on that strain, correct?

There's basically two. Two popular strain. Two popular strain. Exactly. Okay. based on that strain, correct? There's basically two, yes. So if you start reading labels, it's lactobacillus and bifidobacterium. Yes. That's like, yeah, rolls right off the tongue. Yes, sure does. Yeah, exactly.

So how did you figure it out? I put here, I've heard you say, and I know, it's one of the keystone strains for overall health. How did you know that? How did you figure it out? And why hasn't anyone else prior to you in the space of got health ever do anything? Why did nobody ever touch it before? Well, first of all, because we didn't have DNA sequencing before, we didn't even know as a community that acrimansi existed. So even knowing about its existence is relatively new. But even when we people now do know,

like it became like such a blew up and it exploded. Why now, like why did you guys figure this out and nobody else has figured it out? Yeah, well, the challenge is really in manufacturing the strain and in order to know why it's so hard to manufacture the strain, it helps to know, like, what is the strain doing? Why is it so interesting? And what it does is at the heart of having a strong gut lining.

And so, like, I have a wooden fence in my backyard, and it has all these wooden planks, and they're held together by glue. And when I moved into my house, the fence was super strong, the planks are really strong, the glue is strong. But over time, the planks started to, you know, the glue will start to weaken, the planks will start to weaken, a plank can fall. Our gut lining is literally exactly the same. We have these planks, and we have this glue that holds the planks together,

and the glue is called mucin. And basically, what happens over time is we age, as we go through periods of stress, as we change our diets, even like as we travel, is that those, that glue can start to weaken, those planks can start to fall, and the same thing can happen in our gut that is happening to the fence that, you know, we all know about. And what Acromanceia does, it is the only strain that's known to literally live in the gut lining, and all it does all day and all night is it regulates that gut lining. It pulls the old glue off when the glue gets old, it puts new glue on, and it just keeps those planks strong. And so what people had identified was that,

as you age, as you gain weight, as you, for us women, as you go through menopause, there are all these different things that happen that cause you to become depleted in acrimansia, and when you become depleted in it, you now can no longer regulate that gut lining. And when a plank falls in your gut lining, you've got a whole host of problems that start to come out of that. So how did you even know about this?

I had it, like, if it was never even until 2010 or 2012, even known about this, how did you figure it out? Because I mean, I've never heard of it. Like, how did you even start? Well, the scientific community has actually been studying it. So I'm not going to take all the credit for, you know, everything that's been heard of it. How did you even start? Well, the scientific community has actually been studying it. So I'm not going to take all the credit for everything that's been known about it. But the way we started was we basically said,

we've always been super interested in the gut metabolism axis. And the fact that everything that you eat after it goes into your stomach is metabolized by your gut microbiome. And so there's such important things in your gut that are helping you with your metabolism that had never really been unlocked before.

So that's always been really our focus is how do we metabolize food and our gut microbiome and how can we help people metabolize food better. And so when we learned about acrimansia kind of being at the gut lining, we were like, this was interesting. But there's like a long list of strings that were super interesting. The key thing that we discovered was that if you take people

who are obese and you compare them to people who are thin, you see that people who are obese are depleted in acrimansia. And then moreover, if you look at twins that are discordant, where one twin is healthy and the other twin is obese or has type 2 diabetes, you'll see that the healthy twin has a ton of acrimansia and the obese or the type 2 diabetic twin has like very little or almost none. And these are two people who are like genetically identical. And so that started to give us a clue of, okay, well, if there's this sort of broad correlation where people are low in acrimansia and that's associated with obesity and diabetes

and it plays this really important role in the gut lining, like maybe there's something to how it's working and helping people metabolize their food better. And so that was kind of how we got started. But there's other strains besides acrimansia that are in the list of things that help you metabolize food. But acrimansia is just really important because of that role in the gut lining. So those other two strains are super popular.

Did it not show the same type of effects on obesity as acrimansia did? No, not at all. So it not show the same type of effects on obesity as acrimansia did? No, not at all. So I want to know the differentiate. So besides that's a great one. That's in itself. Like everyone's gonna be buying a ton of it just for that. So there's a whole correlation between weight loss, obesity, and acrimansia. That the other strains that you saw, I just want to make sure, did not have, right? What are some other differentiates? Like, what are other things that differentiate

acrimansia from other strains that most other people are using? Yeah, so first of all, it's that it lives in the gut lining. Oh, and then just to get back to why it's hard to manufacture, where it lives, there's no oxygen. And so, you have to create a manufacturing plant that end and end doesn't allow a single molecule of oxygen in, which of course is everywhere in the air around us. So that is one of the biggest

challenges. So how do you create an oxygen free, like totally oxygen free environment? And then secondly, how do you mimic this like mucin layer, this kind of like sticky gluey place where this guy lives in a manufacturing plant? And so those are some of the really big challenges in how do you even grow this strain. And so, you know, as we think about what its role is, that's what led to kind of the difficulties in manufacturing. And then what's kind of emerged over time is that acrimansia doesn't just play a role in helping you with your gut lining. There's new evidence emerging that acrimansancy can also help stimulate GLP1 production.

And so there was this really seminal study that came out last year, and it's the first study to ever show a strain can stimulate GLP1 production, and that strain is acrimancy. And as many people might know, GLP1 drugs are kind of becoming incredibly popularized because of their ability to help people lose weight as well as feel full and not, you know,

want to keep eating. And so it is incredible that Acrimansia is able to stimulate GLP1, you know, this is a natural way it works. So for people who don't know what she's, but what Colleen is talking about is that is basically ozemic and wagovian and all these very, very popular, they're diabetes drugs, but everyone in their dog, I feel, are on it for weight loss. And so, can you tell people how it works

in, like, how it works? Because I think that it's, there is confusion also how even ozampic is working for people. How is it making people feel satiated? And how does this mimic it? Like, you just explain that. I think a lot of people want to know that. Sure. Okay. We'll do some little biology lessons here. But do it in a layman's term, please. Yes. Okay. Okay. So, what happens every time that we eat food is that your gut microbiome, your gut bugs, metabolize that food. And what happens when it metabolizes that food is that it stimulates these cells called L cells, which are actually at your gut microbiome to produce GLP1.

So a lot of people don't know this, but GLP1 actually comes from your gut microbiome. And so you eat food, your gut microbiome, all these bugs are doing their work, and they're like, we just ate, stimulate GLP1. GLP1 is a signaling molecule that has three really important things it does. The first is that it goes out and it stimulates insulin secretion. So that's

essentially how your body metabolizes sugar. And so it is the signaler that goes out and stimulates insulin production so that your body can start metabolizing all the sugar that you just consumed. The second thing it does is that it is able to, and this is still kind of unknown how it does this, but it is able to send signals to your brain to tell you we're full. We just ate, we don't need to eat again. And so it sends signals to your brain to let you know like we don't need to be eating any more food. And the third thing is it slows down the processing of your food so that that actually also gives you a feeling of fullness. So it does all these things to help you metabolize the sugar that you just ate, as well as to tell So it does all these things to help you metabolize

the sugar that you just ate, as well as to tell your body, we don't need to keep eating food. And so what happens naturally is that every time you eat, GLP1 levels go up in your blood, it does all of this work of telling you, we just ate, we're full, and we better metabolize all this sugar,

and then it goes back down. And then the next time you eat it goes up and it goes down. And that's kind of your natural body cycle, and acrimency is the strain that tells the body, let's release GLP1. What these drugs do is they've made a chemical that looks just like GLP1, the signaling guy, and it is delivered directly into your bloodstream. And basically it does all those same functions, but the way the drugs work is you keep GLP1 at a high level at all times.

And that's why it's so potent so quickly. You're basically telling your body all the time, we just ate, we better metabolize all this sugar, and we just ate, we better not eat more food. And so you don't feel hungry and you lose weight. Wow, so basically is it working on people who those signals are dormant in their body or they don't work as well?

And so if you bring in an ozampic or whatever, it's basically accentuating that feeling. Does your body acclimate though? And is that why you have to take more and more as you get used to the amount? So first of all those drugs were all designed for people with type 2 diabetes. So we think about the spectrum of obesity. There's obesity, pre-diabetes, and then type 2 diabetes at So when you think about the spectrum of obesity, there's obesity, pre-diabetes, and then type 2 diabetes at the far end. And so everybody's kind of on the spectrum, right, right, somewhere on the spectrum.

And so people with type 2 diabetes, they really, they have lower levels of GLP1. Their cells, the cells that produce insulin are not as responsive. And so they really need these GLP1s to help stimulate those, they're called beta cells, to stimulate those cells to produce insulin. And they really need these GLP ones to help stimulate those, they're called beta cells, to stimulate those cells to produce insulin. And they really need this GLP one because their GLP one levels are really low. So they need that signaler to say we

just ate something. And so they were designed for people type to diabetes. And actually when we first designed our flagship product and identified acrimansia, it was also for people with type two diabetes. But it turns out that these are all the pathways that operate in our body, and so they also work for people that don't have diabetes. But to answer your question, the issue is that if you are that loud person, you know, with the mics sort of saying like,

we just date, we just date, we just date. Eventually, the receivers kind of go deaf to it. It's just like, if that was what you do. They just like tune you out. They tune you out, and that happens in your body too. So eventually these beta cells are like, right, right, right. And they don't actually produce as much insulin. And so that's why you end up having to, you know,

take more. So can people take acrimansia instead? Like would it work as effectively as, like, maybe not as, but what if they didn't take ozampic and took acrimansia? What would be the effects? Would they still get the same effects, but maybe not as fast and severe? And then would you have to like double the dosage, the same way you would with ozampic? Well, the truth is, you will never see the same impact with acrimansia or something natural as you do with the drugs,

because of the fact that the natural way is to go up and down in GLP ones and what those drugs do is they artificially kind of keep it high for all time. So the good news is you won't get those crazy side effects, but the bad news is you're not gonna drop all those pounds right away. But while you will feel it are those same effects, and actually we just did this study

where we found that 90% of people in Acrimansia have lower food cravings across all the different kinds of food cravings. So carbs, fast foods, fats, and sugars, everybody had lower food cravings. By how much? 90% of people had lower food cravings. It depends on what your starting point is. And so the people that had higher starting food cravings actually had a larger drop than

people who had lower starting food cravings. But in any case, that food craving thing is a big part of the GLP1 effect. So you won't see the same effect as you do with the drugs, but if you wanted to take them in conjunction with the drugs, you're basically going to have the drugs delivering GLP1, and then you're now going to have your body delivering GLP1. And so you're kind of giving yourself extra amounts, in which case you might be able to play around with how much of the drug that you're actually using. If you don't want to be on drugs, maybe you don't have type-d diabetes and you don't want

to be on a drug for diabetes. It's also expensive. It's like $1,000 or $800 a month just to be on these crazy injections. It's definitely pricey. And you gain the weight back when you're off. You gain the weight back when you're off. That's right. Well, because you're now no longer like constantly telling your body like we just ate. And you get hungrier. Why do you get

hungrier afterwards? Like your body? I think it's just a rebound effect. You don't realize like you were always kind of that hungry beforehand. Oh wow. Now that you're off and you've gotten accustomed to not being as hungry. Now listen, it feels like oh my gosh, why am I hungry all the time? Yeah, I'm starving. Yeah. But with acrimansia, you'll never hit those that same kind of level. But what you will be doing is to be allowing your body to naturally produce this GLP1 molecule. So you will be reducing your food cravings and you will be experiencing the improvement in blood glucose.

Your body is going to metabolize your sugars and carbs better. And so it's a natural way for you to stimulate GLP1. And we know that people lose acrimancy over time, and so it's a great way to just replenish your system that your body naturally is supposed to have. Right. So is there any, you can't really, and you can't get it in food, right?

There's no other source that you can get acrimancy, except for in this type of situation. Well, this is sort of the big mystery of where do you get acrimancy? Where can you get it from? From natural, without any supplement or any way. Like, because nobody knows, basically. Yeah, there's never been a food found that has acrimansia in it.

Acrimansia's been found in mother's breast milk, so the theory is like, that's kind of where it gets started. And then we don't know where else you can get it from. You can stimulate, like if you have low levels of acrimansia in your gut, you can stimulate growth through different prebiotics. So polyphenols and fibers can help stimulate the growth of acrimansia in your gut, you can stimulate growth through different prebiotics. Polyphenols and fibers can help stimulate the growth of acrimansia. That's the only other way to do it. I saw grapes that have it, of course, because polyphenols, green tea, but it's not as potent

obviously. I always tell people it's great to do them in conjunction with each other. If you can be taking the prebiotics, feed the probiotic. So if you can be taking the food and the strain itself, you're basically giving yourself the two pieces of the puzzle you need. I want to take a quick break from this episode to thank our sponsor, Therasage. Their trilite panel has become my favorite biohacking thing for healing my body. It's a portable red light panel that I simply cannot live without. I literally bring it with me everywhere I go.

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Well we have 22 patents filed and 65 pending. We have invested a lot in patenting. I can imagine. And it's used in the manufacturing of it. And it's essentially illegal for anybody else to sell this strain here in the United States. Oh wow. That doesn't stop people from trying.

So all the same people. And what's crazy is that we see these popping up on Amazon. We send them to be sequenced by a third party. They come back and they're like, it's actually it's lactobacillus and not even acrimansia And so people are because this is not a it's not regulated Regulated so anyone can say whatever they want so anyone can slap any label on that they want and not even really have truth in the bottle That is terrible. It's terrible and we spend a lot of time

Unfortunately kind of chasing down I can imagine that behavior Yeah, but I guess that could be with lots of different things right because you can make claims about anyone can make a claim Unfortunately, kind of chasing down. I can imagine. That behavior, yeah. But I guess that could be with lots of different things, because you can make claims about anyone can make a claim. And unless someone has the wherewithal or the time or the energy or the money to test it, then they just don't know. Yeah.

But I would say that for us at the core of the company, we've always been centered around building things that really help people in meaningful ways. If you take the product and you don't have reduced food cravings or better energy or better metabolism of your sugars and carbs, we actually know that acrimencia can reduce inflammatory markers like IL-17. So if you don't have these benefits that you can feel after taking the product, we tell people like, don't keep taking it.

Don't take it just for fun. Right, right, right. Take it because you're feeling a benefit from it. And so all I can say about all the hoax companies out there is that if you're taking one of those and you're not feeling anything, it's because it's not the real thing. It's not the right, it's the right, yeah.

And then what would be the symptoms, like low energy you said, cravings, all those things, would be potentially the reason why people have those things is because they have a low acrimency level in their body. Exactly. The kind of things to be looking for are first and foremost, GI discomfort or GI issues, or if you've noticed

that bloating, pain, gas, all of those things, and especially if you've noticed that over time, you now have sensitivities to foods that you didn't use to be sensitive to. That means something's changed in your gut. And so GI discomfort is one of the first things. The second thing is an inability to maintain a healthy weight. So if you've kind of, and our metabolism slows down over time,

but one of the big reasons our metabolism slows down over time is that we lose the strains that are helping us metabolize our sugars and carbs. And so if you're having a hard time maintaining healthy weight, it might be because you're depleted in those gut bugs that are metabolizing sugars and carbs for you. If you have food cravings and you're like, man, I never used to have cravings like this before, again, it's because you might be missing these bugs that are helping you send these GLP1 signals to tell your body, we don't need to keep eating, we're okay here.

And then the last thing is really around energy. So if you kind of have these post-launch slumps or you're not sleeping as well or your workouts aren't as strong, you're just noticing that your energy is starting to fade, that's another signal that you might have lost these strains that are really there for your metabolism. So this gut metabolism axis, when it's gonna rye, it shows up with GI issues, weight, cravings, and energy. Okay, because I take this, the metabolic daily. Acrimansia is in metabolic daily, right?

So, when do I take acrimansia by itself? When do I take metabolic daily by itself? What's the purpose of taking one and not the other? Like, what is the difference? So, you're right. Acrimansia is in metabolic daily. Metabolic daily is a formulation of five different strains, one of which is acrimansia.

And metabolic daily is designed to help your body metabolize sugars and carbs, because acrimansia doesn't really function all by itself. It has other players that help it with this metabolism, and so the full set of players are in metabolic daily. So, if I just took this acrimansia and not metabolic daily, wouldn't it just be better to take this that has acrimansia and it has all these other benefits that you're gonna, like what I feel is like the reduced sugar cravings effectively working carbs,

but more efficiently, all those things. But if I'm getting, if acrimansia has all that as part of the benefits, why would I just take acrimansia? Well, because it depends on really your gut and what you're depleted in. So you might only be depleted in acrimansia? Well, because it depends on really your gut and what you're depleted in. So you might only be depleted in acrimansia. That's your missing link to this whole pathway. It's like you're on a soccer team and you're missing the striker.

Yeah, you're never going to score. Yeah, yeah, yeah. But it's also possible that you're missing a defender or two, right? And so metabolic daily is the full cast that helps you do that metabolism. The whole team. The whole team is there. And then acrimansia is really the one that is, you know metabolism. The whole team. The whole team is there. And then acrimancy is really the one that is the keystone strain.

And it happens to be the one that people are most frequently sort of depleted in. So it's possible that all you're missing is acrimancy, and you can get all those benefits just by giving yourself back acrimancy, or it's possible that you need a lot more of the strains that are in this pathway, and then you would take metabolic daily. And then you actually have another product

which we're not going to talk too much, I guess, about today, which is pendulum glucose control. I do love that one, by the way. That's the one that I take. That's okay, but the reason why I didn't even bring it up yet is it's more expensive because it's way more potent, right? Yes, it is the clinical grade version that has been tested in people with type 2 diabetes.

It's basically exactly what is in metabolic daily, but at a really high dose. So it's more expensive, it has to be refrigerated, and it really was designed and intended for people with type 2 diabetes. Yes, I was going to say, so basically the way I was even sold on it back when was met form and for the met form is this long-jevety drug, I guess, that I don't know. People have been talking about it forever, but it's a drug.

And everyone I know is on it. So, of course, all these people were on, I'm like, okay, I'll be on it. I didn't let that was years ago. I took myself off of it. And a lot of people were like telling me afterwards, oh yeah, I'm no longer taking Metform, I'm taking glucose control.

I substituted it. It's like the natural form of Metformin. By the way, I'm asking these questions as if this is not, this is me literally just asking these questions. This is not kind of one of those things where I'm just giving you softball things. I really want to know.

Is glucose control like a metformin? Does it work as well? What's the, tell us about the longevity properties? Does, when you talk, you're the expert. Well, one of the tell us about the longevity properties? Does it mean you talk, you're the expert? Well, one of the most interesting things that's coming out around longevity and healthy aging is that one of the biggest indicators that tells you if you're gonna be healthy, aging healthy

is how your body metabolizes sugar. Right, so that's a big topic right now. That's a huge topic right now, and it's true because as we age, we know, I mean, you don't need a doctor or a scientist to tell you this. We all know that we don't metabolize sugars as well. Right. Sugar's and carbs start to become the big, big time enemy.

And so, you know, people who are aging in a healthy way are able to continue to metabolize sugars and carbs efficiently and effectively. And that's why these drugs, which are intended to help people with sugar metabolism, or people with type 2 diabetes, end up being used for longevity purposes, is because what they're really doing is they're helping you metabolize your sugars and carbs better. And so you're right,

metformin falls in that camp, you know, I think GLP ones are first discovered by biohackers for that purpose. We were first discovered, Penjland-Gugos control was first discovered by a bunch of biohackers for exactly the same thing. They were slapping on continuous glucose monitors, and I will throw myself,

I'm not a biohacker, I'm like a wannabe, but like I wore continuous glucose monitor and tracked what pendulum glucose control did for me. And so, my friends, that's how I knew about it. Yeah. And so the heart of like, do these drugs work for longevity is because they're helping you

metabolize sugar. And so, this trials that we've done with metabolic, oh sorry, with pendulum glucose control were in people who were already taking metformin. So it has an even additive benefit on top of taking metformin. And so what's unclear is whether it's additive because it's functioning totally differently or if it's additive because you're just now got your metformin and now you're just almost like you're taking more metformin.

One of the biggest side effects that people experience with metformin is GI distress. And so what we found was that people were telling us, oh, when I'm on glucose control, I can now take my full metformin dose. Like, now I'm really like a rock star metabolizing sugars. Oh, wow. So people are taking both of them. They're people who are taking both of them. Oh, I was under the impression, or I think, like, people I know, just didn't do it anymore and just started taking the glucose control.

Well, a lot of people don't really want to be on drugs. No, and so they're a goal, some people don't really mind. Yeah, and so their goal is to kind of tight-treat down or get themselves off of the drugs. And so that's where they start to use, they're starting to use our strains and formulations. But a lot of people, they don't mind taking drugs and our formulations on top of that. And so they're just double downing. They're double downing. So you take the glucose control you said and what has it done for you?

I take the glucose control. I'm a big nerd and so I didn't experiment on myself. Yeah, and I also think that- You should be a nerd, you should company. I think the chef should always eat their own cooking. They should. And so in the very early days, I slept on a continuous glucose monitor and I took pendulum glucose control and then I also took placebo. So I did kind of a placebo trial on myself. Oh, okay. And I made myself blinded to all the CGM data until the very end of my little study.

But I knew when I was on Glucose Control because my workouts were stronger. For me, it showed up as better energy. And so my workouts were stronger, I could go for longer, and it was just like, oh my gosh, I have better energy. And then I kind of didn't get those post-lunch slumps that I normally get after eating lunch

in the middle of the day. Like if you want to get information for me at 2 p.m. versus 9 a.m., you're getting like a much dumber calling at 2 p.m. Tell me, bro. And so I noticed that I was, you know, not as smart as at 9 a.m. but definitely smarter than I used to be.

And so for me, I knew when I was on the product. And then when I unveiled my continuous glucose monitor data, I was like, holy smokes, this is what's, this is why. All of my peaks and spikes, every time you eat, gets a glucose spike and then a crash. All of them were minimized when I was on the product versus on the placebo. And so then I just, I mean, I don't have prediabetes

or type 2 diabetes, but I am aging. And I do know that my body can't metabolize sugars and carbs as well. And so I'm on that full formulation because I saw that data and I know what it does for me. And I also, you know, it helps with satiety, like not having cravings. So you don't have cravings at all on it? Well, I don't want to say I don't have cravings at all.

But I will say that it's better. It's better. By what percentage would you say it's improved? For me, it's really about certain foods. So it's almost like binary, so I really don't have sugar cravings. I do, if you want to put alcohol into a bucket of craving, I definitely still enjoy my alcohol,

and I am a little bit of a sucker for salty snacks, but it's my thing too. I can have a cake out on my countertop and walk by it every day until the cake has been finished by other people. And I, maybe it'll be really. Yeah, so it's pretty like I don't have sugar cravings anymore at all. So what is the difference in potency between the glucose control which has to be refrigerated?

And let's say the metabolic daily that does not have to be refrigerated. Yeah, so it is about five times more potent. Oh wow. Yeah, so it's got five times more potent. Oh, wow. Yeah, so it's got a lot more stuff in it. Yeah, and it's more expensive, but I heard it's because it's also very expensive to make. It is very expensive to make. And so actual strains, super expensive. The strains are, I mean, we had to build a manufacturing plant because nobody else could grow these strains. And so over time, we will figure out how to lower the cost of these strains. And actually, we, Accuromancy is a good example where after we launched Accuromancy, we sold

out, people were really loving it. We actually didn't even realize how many people were looking for Accuromancy. If you take a gut microbiome test, a lot of times it shows up kind of at the top, oh, you're low in Accuromancy. So we really kind of put our noses to the grindstone. We're like, we have to figure out how to make Accuromancy less expensive. So when we launched Accurromance, it was, I think at like $85 a bottle,

and then we've been able to lower the price because we've been able to figure out how to grow acromance at a lower cost. And so now I think that, actually this is terrible. I don't even know what we sell acromance here for. I think it's like, I think it's like 59. I thought it was 49. Yeah, it could be 49. Yeah, I don't know. I don't even know. But anyway, it's like, I think it's like 59. I thought it was 49. Yeah, it could be 49.

Yeah, I don't know. I don't know. But anyway, it's much less. It's a subscription based model, guys. So basically what happens is you buy it, and they bring it every 30 days you get replenished, right? That's basically what happens with me anyway. But it is much more cost effective than the glucose control.

And also metabolic daily is almost the same, is the same price as accurements. Yeah, exactly, exactly. It's much more affordable. It gets below the $50 price point. And I think for a lot of people, as I said, it just depends on what you're low in. And the truth is, I might be able to get away

with metabolic daily, but I just haven't. You haven't done it yet. Well, you're the owner, I would hope that maybe it's being the CEO and founder, one of the founders. Maybe you can take your own product. I think that makes sense to me. What else is in the glucose control, is that the same ingredients exactly

as the metabolic daily, just five times more potent? Yep, exactly. And it has acrimansia in it. And it has acrimansia. So that means it has five times the amount of acrimantia. It has, yeah. How much acrimantia is in the acrimantia? Like how much is in this one?

That one has 100. And I believe that there is, this is terrible because we have to play this game of trying to guess. So all of these products have a two-year shelf life stability. So now we're gonna get into quality control. So everything has a two-year shelf life stability. And what we want to put on the label is the amount that you would be taking if you were taking it at the two-year time point.

So actually when you first get this bottle, you're actually taking more because what happens over time is it loses both of your time. And so what's on the label is sort of like if you took it at the two-year time point, we're guaranteeing that you're going to get at least that amount. So you're actually getting more at the beginning. Is everything? Like that's what they do for... That's what we do. Not all supplements do Is everything? That's what they do for... That's what we do. Not all supplements do that, but that's what we do because we are basically guaranteeing you're getting

at least that, and you're likely getting more than that. And if you are on the every 30-day model, you're definitely getting multiples of that. So at the end of the day, I'm actually not exactly sure if it's two or three X, more acrimansia than there is in here. There is more acrimansia in here. Right, in the acrimansia. In the acrimansia, the pure acrimansia pill. So I here. There is more acrimansia in here. Right, in the acrimansia. In the pure acrimansia pill.

So I'm taking both, I can told you, but that's very interesting. I didn't know that, how that would work like that. So there may other, I have a few other questions if you don't mind. Yeah. So how do you check someone's metabolism? Like what's the biomarker?

I mean, I know that with the glucose control and metabolic, I mean, with them you can see certain biomarkers shift and change, but with overall metabolism, how do you know if you're a metabol, that's a very arbitrary thing, right? So it says here on the bottle, it says optimized metabolism with metabolic daily, right? How can you really check to see

if your metabolism is better on day 90 versus day one. Can you check that? Yeah, so the way that we measure metabolism is A1C and your blood glucose. And that's why when you, people with type 2 diabetes are basically at this end of the spectrum of their metabolism kind of being totally disrupted. And so your metabolism is sort of slowing down

as you go into obesity, pre-diabetes, and then it's like really, really messed up once you have typed two diabetes. And so the kind of gold standard measurements of metabolism are what is your hemoglobin A1C, and what is your, you know, what are your blood glucose spikes, and then kind of what's your fasting blood glucose level. And so those are kind of the hallmarks of metabolism. Now, not all of us are like going in and wanting to get our A1C measured and our blood glucose spikes and wearing a contidue,

so it goes modern and all that. So there are a lot of soft ways in which you can know, you know, not necessarily those hard end points through your blood work, but there's a lot of soft ways that you can know that your metabolism is improved. And it's basically just the opposite of when you know your metabolism is slowing down.

So again, it's like, you know, if you have a particular portion size, your body is able to metabolize it faster. You don't get this really high spike and then this crash. So you don't get exhausted when your body is crashing off of that sugar. You are able to, so that's really around the sustained energy, and you're able to eat the same portion size and not gain weight. And so it's really all the things that we know that we have to do

as our metabolism slows down. Oh man, I have to eat less food now in order to maintain the keen weight. And so it's really all the things that we know that we have to do as our metabolism slows down. Oh man, I have to eat less food now in order to maintain the same weight. Your metabolism is slowed down. And if your metabolism stays the same, that means you get to get the same amount of food and you stay the same weight. And so that's those are kind of the markers that you don't need a blood work to tell you. Exactly.

It's more like basically tracking your own lifestyle and common sense. Like well, do you feel bloated? Do you feel, do you have, if you have implementions, whatever, I guess implementions a different one, but bloating or energy or all those things that you don't take a test for. You just, you know. You know, right?

And that's the thing is sort of the beauty of these products is that you know, you don't, you can go take the blood test. Of course, you know people and I know people and I'm that person too, which is we did the, you know, we got the blood work done to prove to ourselves that I saw a difference in my numbers. Yeah. Exactly.

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risk-free for 60 nights at blissy.com slash hustle and get an additional 30% off. That's blissy.com slash hustle and use code hustle to get that additional 30% off. Sleep cooler this fall with blissy. I'm super excited to share my latest health obsession with you guys. It's called Metabolic Daily by Pendulum. Metabolic daily is a powerful, multi-strain probiotic that really improves your metabolism, reduces your sugar cravings, breaks down carbs more efficiently, and sustains your energy. I've been taking Metabolic daily for a few months, and it's unbelievable the results I've seen. Not only do I never struggle with my cravings, but I'm seeing a huge improvement in my body composition from breaking down carbs more effectively.

I love penitent, because they are really disrupting the probiotic market with clinically studied strains that aren't available anywhere else. They were founded by PhD scientists and are backed by the Mayo Clinic and Halle Berry, who recently became their chief communications officer because of the results that she's seen. They're the only company with, I think I'm pronouncing this correctly, it's called Acrimansia, a next generation strain

that's called the Keystone strain for gut health. You can get it as a single strain or in metabolic daily. Plus, you guys can take 20% off your first month of any Pendulum Product Membership with this code, Jen Cohen. So go now to PendulumLife.com and use my code at checkout. Trust me, you will feel incredible. So that's the thing, like, I started this whole podcast by saying that you guys are like, a notch above all these other companies out there who are basically going out there

and promoting God Health and microbiome. Like the science is behind you're doing something incredibly unique with the acrimansia, which is something that no other company I saw was doing. And like you're, like I said, people, you guys, if you want to, you know, do the testing of taking your blood before or after 90 days, 60 days, whatever, I think everyone would be surprised and pleasantly surprised at what they actually see. Let's get into the quality control because obviously that's what we're talking about. How are you able, you said you have your own manufacturing plant because no other manufacturing plant was able to actually even create these drugs, right?

What a production. How many people are there now? Like, what's how big is this biotech company now? Well, our company's not that big actually. We are still a startup, so we have less than 100 people in the company total. Okay. And San Francisco's your home office.

San Francisco's our home office, it's also where the manufacturing plant is. And so, it is still a small but, but hopefully growing company. Yeah in the mighty. It's every head count. Every head counts. Everybody is like a major contributor. We have an awesome amazing rock star team. So we do all the manufacturing, but when it comes to quality and we have a quality control team, of course, but when it comes to quality control, you really need third parties to validate your product. And so I'm glad you said that.

It's a third, but that's why I wanted to say, so I'm happy you're bringing that up. Yeah, you really need to send it out to other people that are these certified labs that will double check that, okay, this is the viability, that is the count, this is the product that you're saying it is. And so we really use third party validation and third party numbers in order to create

kind of these, every bottle has a certificate of approval associated with it and has these third-party quality validations and measurements. So all of that is available. That's great. Is there anything I forgot to ask you about that's important for people to know in terms of God Health, microbiome, probiotic, immune system, anything besides what we've talked about. Well, I'd love to hear your experience. Okay, yes, right.

Okay, so that's really funny because I actually did something on my story the other day, or maybe it's like, guess when they see this, it will be the other day, did it today actually. But I was telling someone that I work with, I was actually taking this and she was asking me, oh, what is it? And I have seen two things that I, and that's interesting because I do a lot of stuff, right? Like that's the problem with a lot of people who do a lot of things, right? I do the saw and the cold plunges. I exercise every day. I eat very healthy. So it's very hard to really see a significant difference when you're doing all the things, right? And so that's really, that's why I wanna first say, right? But if I were to really think about how it's affected me

in a real way, I would say it is the sugar cravings and I would say bloating and in terms of carbs, efficiently working with carbs more efficiently. Those are the things that I would see that I saw a bump in, which is why again, I was a fan, I am a fan of this, because like I said, I get hit up all the time with probiotic companies. I don't know what one from the other, right?

Like a lot of times I'm like, I don't know, I take so many things, I don't know, I don't notice. This I did see, and I did feel better with. And I did see in my blood that in my bio markers, a difference from day one to day 60 or day 90 actually. The point is, which is why, and I think, which is why there is traction with your brand, and I think when people who are more knowledgeable,

like not these Yahoo's on social media who are saying whatever, I mean, maybe I'm a Yahoo on social media, I can very well be to some people. But I think a lot of people with a medical background, who I'm very good friends with, were really huge advocates for it, and were taking it themselves. That's a big key indicator, right?

When people who are knowledgeable, who know the science, who also are very exposed to a lot of brands, and they are actually basically believers and are adopters in taking it. In my opinion, that's what it's like. I'm very discerning at who I take advice from, and the people that I do take advice from, really were like, yeah, this is different.

This is different. This is way more, this is a science back, this actually is a product that is so much quality control, they're different, they have a different strain and so to answer your question that's how I felt different, I felt this sugar cravings, I felt like less bloating and overall I just felt a little bit better. Yeah, that's great. And I think that it really is, this sugar cravings thing is so crazy. So it's funny we both kind of experienced that reduction. And we have them, don't get me wrong. Yeah, but they're like maybe like they are suppressed

more than they would normally be. Well, and I think it's so important because a lot of us, a lot of people feel guilty when we have cravings and we break and we succumb to those cravings and we just think like, oh man, I wish I had more willpower or I shouldn't have eaten that. Exactly. And you feel bad and you kind of get on to this bad kind of mental cycle about it and really beating yourself up about things. And the truth is that your body has systems in place that help you kind of not have those cravings as badly. You're right. We're all going to have vices and actually I think vices good to have and

that's a separate conversation. It's part of a cute, it's human. We all have, you can only have that much discipline and willpower not 100% of the time. But if there's a tool that can help you naturally reduce those cravings, it just sets you in a totally different mindset. You can feel really positive. I take my glucose control every morning, and for me it's almost like a part of starting my day, which is, okay, it's a new reset, it's a new day, and I'm giving my body what it needs

to help me get through this day, you know, as guilt-free as possible. Well, that's the thing, like I think it's just about, like having, it's not perfection, it's progress. No one's expecting anyone to be perfect, but if it just bumps you a little bit, it's better than zero. And I'm very much on like habits and rituals

and morning routines and all that night routines, blah, blah, blah. This is just part of my routine now. I take very few supplements, almost none. I take vitamin D, I take omega-3. I take actually both of these acrobatics and the metabolic daily. And I take vitamin D, I take omega-3, I take actually both of these acrimencia and the metabolic daily, and I take trinigin, which is an NED precursor. That's basically what I take. And I've been taking those for a very long time, very few times, do I, you know, even think about adding more to the supplement plate. But this was something that,

that's why I wanted to share it, because I think there's such added value. And if people can improve their health just a little bit, it's worth it, right? Absolutely, absolutely. And I will tell you what I take pendulum glucose control and polyphenols. So, remember, we talked about how polyphenols can boost acrimansial levels.

We actually did a study where we looked at a bunch of different polyphenols and picked three that specifically work with our acrimancy. And so we have a polyphenol formulation. So I take the polyphen, yes. And so it's pomegranate, green tea, and grape seed polyphenol blend. And so I take that with my pendulum glucose control just to like boost the acrimancy level. So it's something like a really to just taking acrimancy level. So it's something you're like, and really? To just taking acrimansia. So, and we're... I want you to take the acrimansia

with the glucose control. I take both. I, well, there was one point in which I was kind of a lunatic. I was taking all of the... So I don't want to stop taking glucose control. That's my main problem. I feel like I need to do an experiment. I just like switch off of it and do something else.

But there was a moment where I was taking glucose control, acrimansia, polyphenols. I was just like you know Yeah, seven pills at once and then I had someone I felt like okay This isn't I don't know that I'm really feeling anything here But the polyphenols have other added benefits besides just boosting up in the insia And so that's why I should try it out with that's what I'm doing and then we are getting ready to lunch and omega-3 Which is not official based but a but a vegetarian-based Omega 3. And again, it is promotes the growth

of a different strain, which we didn't talk about, an aerobacteria, an aerobactericum, halai. So what an awful lot is. They're all a mouthful. You gotta go on to Google and ask it to say it, to multiple times. So I'm gonna say, how do you even say it? So it's just like, the low is off the tongue.

Oh yeah, well, I've been doing this for a decade. Yeah, that's true. I've been saying these days are 10 years. But in any case, for 10 years, you guys have been developing this accrimance, yeah. We've been around for 10 years. Wow. For the first eight, we were doing all the data science,

the growing strains, the pre-clinical trials, the clinical trials, and that's what we were doing for eight years before we even launched a single product. So just for the last couple of years, you guys are now maybe more known, but so for eight years prior, you guys were just like in the lab doing all this. We were just doing it all of this too.

No, people haven't let me in the lab for a long time, but we were doing the lab work and the manufacturing and these trials and I- What are you doing? Well, a lot of your job in a startup is fundraising. Fund raising, raising money. Yeah. But I think even this idea of how do you

select the ones that you're going to move forward with? And I wouldn't say, I mean, the science is super interesting to me. And so I was much more involved in the R&D side of things. And even designing our clinical trials, we have an amazing chief medical officer. So I'm just sort of like support for all these things. I'm not like the main person doing them.

But I'll tell you a funny story. The company has always been premised and we want to help people. We're not going to put a product out that doesn't help people. At some point, I was doing a fundraising pitch. And this firm actually brings in every partner. So when you pitch, you're literally pitching to every partner in the firm simultaneously. It's the only mildly intimidating. Yeah, just mildly. Yeah. And so this

was before we had, we had done a pre-clinical trial, but we were looking for funding to run this clinical trial. And one of the partners said, well, if I understand that you figure out how to manufacture the thing, you've got the pre-clinical that shows that it's, you know, has some efficacy. Like, why don't you just launch the product and start building revenue now? Yeah. And I basically got on my soapbox and I said, okay, until we have clinical trial data and we have proved that these products are actually going to help people, we're not going to launch a product. Effectively, what I told him was that I'm going to take your money and if we don't get the outcome that I want, we're just that all is all going to go to waste. We're just going to go back to the drawing board. Wow.

Did they give you the money? And as I walked out, I was like, oh my god, I'm so stupid. Why did I say that? They not only gave us the money, they led the round, and they pointed back to that moment and said, we like to get behind founders that believe in doing something that's game-changing in this world. And when you gave us that answer, we knew that you were the kind of company you wanted to invest in. Really?

And so it actually was, even though I was afraid it was a thing that was gonna turn them off, it was the thing that got them excited. I love that story. Who was the company? Who was the fun? So that's Sequoia. That's Sequoia.

I was gonna say that. And that's the biggest best of them all. They're pretty amazing. And Sequoia is behind like Google, like everybody. Every main, like everybody, every main like major, Apple. So you have Sequoia backing you, which is by the way, I'm telling you guys, that's like major, major. They've been awesome partners because they really think big. It's not about, you know, the small win or what you can do today to like trick people

into buying your product right now. It's about, are you building something that is going to really change people's health in meaningful ways and it's been awesome. They don't normally, they've never invested like a probiotics company. So, you know, we really are a biotech company. And like a company of your size in general, like that to me says speaks volumes, I feel. Well, Sequoia is a large investment fund and they invested every stage.

They invest, like they invested like a guy in a dog all the way through to, you know, I guess that's true. Maybe you're right. I just felt like, I just know them for being like any company that's really like, that's been transformational in the world, like the apples, the whoever, Google's, that's who that's who's backing them. Yeah. So the fact that you got them as your backers for a probiotic company is says a lot, I think personally

It's been awesome and to your point, you know, and it led you around. That's amazing. Yeah, who's who's taking the time to really dig into? Yeah, the next level products you and Sequoia. Yeah Oh my god, I'm a good company at least right? Well, that's amazing. Well calling thank you for being on this podcast. I really appreciate it. And this was very valuable because I, you know, I don't think many people know what acrimantia is. The strain, how it can be beneficial, what's lacking in their, in their own body that may be causing some health gut issues that they can look into as opposed to doing, like looking at the same stone over and over again and expecting to find something different,

which is again why I'm really grateful that you came on. Well, thank you so much for having me and giving me an opportunity to share how the products were. I love it. Come back again. I will, okay. Bye. Oh, where we find you.

Don't leave yet, don't leave yet. Sorry. Yes, so you can find us at pendulumlife.com. And for your listeners, we have a special code, which is GenCoin, which gets you 20% off of your first bottle of membership. And then we also are on Amazon if you prefer to buy that way. Oh, Amazon's always so much easier.

You can just click and go. I know, but when you join through our website, you actually get access to beta products and new information and we share out actually these trial data and things like that. So that's awesome. There's some added benefits to being on the app. Yeah, amazing.

Well, thank you guys. And you guys try it. I'm telling you guys, if you have, if you know what's good for you, you'll try it. I'm telling you. Bye. This episode is brought to you by the YAP Media Podcast Network. I'm Halataha, CEO of the award-winning Digital Media Empire YAP Media, and host of YAP Young & Profiting Podcast, a number one

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